Comprehensive PubChem-Based Research Overview

1. Molecular Identity & Structure

PT-141 is cataloged in PubChem as CID 6918243, with the molecular formula C50H68N14O10 and a molecular weight of ~1025.2 g/mol [1]. It is a synthetic cyclic heptapeptide analogue structurally related to Melanotan II, optimized for melanocortin receptor activity.

2. Receptor Pathways & Signaling Research

According to PubChem annotations, PT-141 is a potent agonist of melanocortin receptors (MC3R and MC4R, with activity also at MC1R and MC5R) [1]. In laboratory studies, it is used to probe GPCR-mediated cAMP signaling, receptor selectivity, and downstream transcriptional pathways, making it a key tool in receptor pharmacology research.

3. Nasal Spray & Epithelial Transport Models

The nasal spray preparation provides a delivery format suitable for in vitro epithelial transport, peptide stability, and mucosal diffusion assays [2]. Researchers apply this formulation in comparative studies of peptide absorption kinetics versus injectable solutions, focusing on delivery efficiency and enzymatic degradation.

4. Biochemical & Cellular Applications

• GPCR binding assaysto quantify ligand-receptor interactions.
• Signal transduction studiesusing cAMP readouts.
• Peptide stability and degradation assaysacross pH and enzymatic conditions.

These applications remain strictly limited to controlled research settings.

5. Data Traceability & Quality Control

PT-141’s PubChem entry includes registry identifiers (CAS 189691-06-3) and standardized structural data [1]. These allow reproducible cataloging, QC verification, and integration into peptide libraries for SAR analysis, bioinformatics tracking, and screening programs.