Comprehensive PubChem-Based Research Overview

1. Molecular Identity & Structure

Selank is cataloged in PubChem under CID 16131159, with molecular formula C33H57N11O9 and molecular weight of ~751.9 g/mol [1]. It is a synthetic derivative of the endogenous peptide tuftsin, engineered to extend stability and bioactivity in experimental settings. The nasal spray format allows direct application to epithelial transport models.

2. Neurochemical and Receptor Pathways

PubChem records highlight Selank as a synthetic tuftsin analogue [1][2]. Research applications focus on peptide–receptor interactions linked to GABAergic modulation and neuropeptide signaling. In nasal spray format, Selank can be evaluated in in vitro mucosal absorption assays and neurochemical pathway studies.

3. Epithelial Transport & Delivery Research

The spray preparation is particularly useful for laboratory studies on epithelial barrier penetration, peptide half-life in solution, and comparative bioavailability models. Researchers employ nasal spray formulations to investigate peptide stability, diffusion rates, and mucosal delivery kinetics in cell culture and tissue explant systems [2].

4. Behavioral & Cognitive Models (Preclinical Context)

PubChem cross-references include experimental data associating Selank with learning, memory, and stress-response assays in animals [1][2]. While these are strictly preclinical, the nasal spray format has enabled controlled delivery in such models, making it relevant for mechanistic studies in neuroscience laboratories.

5. Analytical & Experimental Utility

With clear PubChem identifiers and structural data, Selank nasal spray is integrated into LIMS tracking, analytical QC, and structure–activity relationship (SAR) experiments. This ensures reproducibility and traceability across laboratories testing neuropeptide analogues in delivery-focused experimental designs.