Product Overview:

Product Name: AOD-9604
Quantity: 10mg
Molecular Formula: C78H123N23O23S2
Molecular Weight: ~1815.1 g/mol
Research Use Only. Not for Human Consumption.

Research Applications:

1. Metabolic and Lipolytic Regulation

AOD-9604 was developed by modifying the C-terminal segment (176–191) of human growth hormone (hGH). This region is believed to be responsible for hGH’s fat-reducing effects. Studies show AOD-9604 can stimulate lipolysis (fat breakdown) and inhibit lipogenesis (fat formation) in vitro without exerting significant effects on blood sugar or insulin sensitivity [1].

Its selective activation of lipolytic pathways without impacting IGF-1 makes it an important compound for researchers studying energy balance and fat metabolism mechanisms [2]. These features allow AOD-9604 to be studied in models where hGH-related mitogenic or diabetogenic effects are undesirable.

2. Obesity and Adipose Tissue Models

In preclinical models, especially in obese rodents, AOD-9604 has demonstrated the ability to reduce body fat mass without altering lean muscle or organ weights [3]. It shows preferential activity on visceral adipose tissues and has been observed to enhance lipid mobilization even in high-calorie diet models. Importantly, this effect appears to occur independently of pituitary axis signaling, which distinguishes it from unmodified hGH.

This specificity makes AOD-9604 of interest in research focused on obesity, adipocyte biology, and endocrine-independent fat regulation pathways.

3. Safety Profile in Preclinical Settings

According to animal studies and toxicological reviews, AOD-9604 did not exhibit mitogenic activity or increase in IGF-1 levels [4], key concerns often associated with full-length growth hormone analogs. These findings support its use in studies requiring metabolic modulation with reduced risk of off-target cellular proliferation.